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The EIMS trial showed that combination of the two therapies improved global symptoms and significantly decreased overall pain severity compared to the placebo groups at 12 weeks and 1 year. Additionally, the combination significantly increased proportion of patients who maintained full or partial remission at 12 weeks and 1 year, compared to the placebo group.
Patients in the combination group reported a median reduction in pain intensity of 31% per hour for the primary endpoint Buy diflucan tablets
at 12 weeks (P<0.001), and a median reduction of 29% per hour for the secondary endpoint (P<0.001).
The mean weight loss during 3-month period was 0.7 kg in patients the combination group, and was greater for patients in the combination group (0.9 kg) than in the placebo group (0.5 kg) (Figure).
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Adverse events were reported in 1% to 10% of patients treated with ibuprofen and in 1% to 10% of the placebo group. most commonly reported adverse events were neck pain, dry eyes, and backache. Adverse events were less common among patients who were receiving the lowest dose of ibuprofen (0.4 g/day) than among those who were receiving 3.5 to 5.0 g/day of ibuprofen (9% the combination group, 11% of placebo group).
Nausea was more common in the combination group than either placebo or the low-dose group at baseline (26% vs 12%).
Weight loss, which is an outcome measure in the trial, was greater combination group than in any other at online pharmacy store in usa either end of the study (P<0.001, Figure 2).
Data in the Supplement
The following adverse events were evaluated:
â€¢ Chest pain
â€¢ Laryngitis/upper respiratory tract infection
â€¢ Fluid retention
â€¢ Back pain
â€¢ Skin reactio